Wandering Son

Wandering Son (放浪息子, Hōrō Musuko) is a manga series written and illustrated by Takako Shimura. It was originally serialized in Comic Beam from the December 2002 to August 2013 issue, and published in 15 tankōbon volumes by Enterbrain from July 2003 to August 2013. The series is licensed in English by Fantagraphics Books, which released the first volume in North America in July 2011. A 12-episode anime adaptation produced by AIC Classic and directed by Ei Aoki aired in Japan between January and March 2011.

Plot
Effeminate fifth grader Shuuichi Nitori is considered by most to be one of the prettiest girls in school, but much to her dismay, she is actually biologically male. Fortunately, Shuuichi has a childhood friend who has similar feelings of discomfort related to gender identity: the lanky tomboy Yoshino Takatsuki, who, though biologically female, does not identify as a girl. These two friends share a similar secret and find solace in one another; however, their lives become even more complicated when they must tread the unfamiliar waters of a new school, attempt to make new friends, and struggle to maintain old ones. Faced with nearly insurmountable odds, they must learn to deal with the harsh realities of growing up, transexuality, relationships, and acceptance.

Lauded as a decidedly serious take on gender identity and LGBT struggles, Takako Shimura's Hourou Musuko is about Shuuichi and Yoshino's attempts to discover their true selves as they enter puberty, make friends, fall in love, and face some very real and difficult choices.