Homunculus

Homunculus (ホムンクルス) is a Japanese manga by Hideo Yamamoto, intended for the seinen audience. It is serialized in the magazine Big Comic Spirits. The first volume was released by Shogakukan on July 30, 2003, the last volume on April 28, 2011.

Plot
Trepanation is the procedure of drilling a hole in the skull. It is said to increase the blood circulation and improve pressure inside the skull. It is also said to bring out a person's sixth sense, the ability to use ESP, see ghosts, move objects with one's mind. This is speculative fiction based on the concept of trepanation.