Hakkenden

Hakkenden: Eight Dogs of the East (八犬伝 ―東方八犬異聞, Hakkenden: Tōhō Hakken Ibun) is a manga series written and illustrated by Miyuki Abe. An anime adaptation of the manga, produced by Studio Deen, premiered on January 5, 2013. A second season premiered summer of 2013.

Plot
Five years ago, almost every villager of Ootsuka died due to a tragic plague. But mysteriously enough, three survivors: a girl and two boys, emerged. Now living in a church, the three live in isolation, hidden from those who may seek to find them. Shino, one of the survivors, has control over the power of Murasame, the blade of life. But when the imperial church seeks to take the Murasame for themselves, their peaceful life becomes a thing of the past...