Otome Youkai Zakuro

Otome Yōkai Zakuro (おとめ妖怪 ざくろ?, "Maiden Spirit Zakuro") is a Japanese manga series written and illustrated by Lily Hoshino. It began serialization in November 2006 in the monthly seinen manga magazine Comic Birz. The first tankōbon volume was released by Gentosha in January 2008; as of January 2013, seven volumes have been released. An anime adaptation produced by J.C.Staff and directed by Chiaki Kon began airing in Japan in October 2010.

Plot
Westernization, a time when humans and spirits coexist.

The modernization of Japan has begun. The Ministry of Spirit Affairs is established to resolve mysterious incidents involving the nation’s spirits. This ministry consists of representatives from both the human and spirit worlds. Zakuro, Susukihotaru, Bonbori, and Hozuki are all half-spirits who have been partnered with the second lieutenants Kei, Riken, and Ganryu. These half-spirit girls and the male second lieutenants are all assigned to Spirit Affairs in an effort to join forces and carry out any tasks given to them!

Official

 * Otome Youkai Zakuro
 * Otome Youkai Zakuro

Other Sources

 * Otome Youkai Zakuro on Wikipedia
 * AnimeNewsNetwork