I don’t really watch girl protagonist but I’ll test it

Manga, Akame Ga Kill. Main characters are kind of villainous anti-heroes and trying to take down a corrupt empire. Plus if you like it, there is a prequel and sequel.

I second Talentless Nana. I don’t normally watch anime with female MCs either but that one was really good.

Monster. Johan is by far one of the best antagonists ive seen.

I watched that but i said protagnist

Oh klkl. Have u watched code geass or neon genisis evangelion?

Yeah its up there

Id recommend neon genisis then

Is that a girl protagnist

No, Shinji is