The series was adapted into a twenty-six episode anime series entitled E's Otherwise (エス·アザーワイズ) by Studio Pierrot. It debuted in Japan on April 1, 2003 on TV Tokyo; the final episode aired on September 23, 2003. Two light novels and three drama CDs related to the series have also been released in Japan.
Broccoli Books licensed the manga series for English-language publication in North America in 2006. ADV Films licensed the anime series for North American broadcast and distribution, with the English dubbed version of the series airing on Anime Network.
The series focuses on Kai Kudō, an "Esper", who is recruited by an organization called Ashurum to become a soldier to purportedly save other psychics from regular humans. After a mission in Gald goes wrong, Kai finds himself living with a man named Yuuki and his adopted sister Asuka. As he learns more about Ashurum, Kai finds himself wondering what their true goals are, and worrying about his ill sister, who is under Ashurum's care.