The first novel was published in Japan in May 2003, with the final novel published on July 2003. The novels were later adapted into a manga series and an anime film trilogy.
Viz Media licensed the novels and published all three in one volume. Kodansha Comics USA published the manga series, which was drawn by Yoshitoki Oima, in English, and Sentai Filmworks released anime films on DVD and Blu-ray Disc.
Taking place in a futuristic city called Kamina City, Rune Balot is a prostitute who was taken in by the notorious gambler Shell Septinous. One night, Shell abandons Rune and attempts to murder her in an explosion. However, she is rescued and transformed into a cyborg by Dr. Easter under regulation Mardock Scramble 09, an emergency ordinance where experimental technologies can be used to preserve life. An Artificial intelligence who takes the form of a Mouse accompanies her to adapt to her new life. Rune is trained to use the advanced technology fitted on her to defend herself against Shell's attempts to have her killed to stop her from testifying against him.