The manga was serialized in Tokuma Shoten's Shōnen Captain from the series debut in 1995 until the magazine's demise in 1997. The series continued in Shōnen Gahosha's Young King Ours magazine, under the title Trigun Maximum (トライガンマキシマム, Toraigan Makishimamu), where it remained until finishing in 2007.
Trigun was adapted into an animated television series in 1998. The Madhouse Studios production aired on TV Tokyo from April 4, 1998 to September 30, 1998, totaling 26 episodes. An animated feature film called Trigun: Badlands Rumble was released in April 2010.
Known for its Space Western theme, Trigun is about a man named "Vash the Stampede" and the two Bernardelli Insurance Society employees who follow him around in order to minimize the damages inevitably caused by his appearance. Most of the damage attributed to Vash is actually caused by bounty hunters in pursuit of the "60,000,000,000$$" (sixty billion "double dollars") bounty on Vash's head for the destruction of the city of July. However, he cannot remember the incident clearly due to his amnesia. Throughout his travels, Vash tries to save lives using non-lethal force. He is occasionally joined by a priest, Nicholas D. Wolfwood, who, like Vash, is a superb gunfighter with a mysterious past.
As the series progresses, more is gradually learned about Vash's mysterious history and the history of human civilization on the planet Gunsmoke. The series often employs comic relief and is mostly light-hearted in tone, although the tone shifts toward darker and more dramatic situations as it draws to a conclusion. It also involves moral conflict pertaining to the morality of killing other living things, even when arguably justified (i.e. self-defense/defending others).